
J***********************a
Profil
Bildung
“FibrilPaint as a novel tool to unravel the molecular mechanism of neurodegenerative diseases” | Magna cum laude
Thesis: “Design and development of small molecules to target tau and α-synuclein aggregation” | Grade: 9.1/10
35 ECTS credits in the master’s degree programme in Toxicology and master’s degree programme in Biomedicine
Thesis: “Study of Tuberculosis in Drosophila melanogaster model. Infection in Mycobacterium marinum” | Grade: 9.1/10
Erfahrungen
- Performed recombinant protein production and purification and brain-derived protein purification - Developed and validated a sensitive peptide-based assay for early diagnosis of neurodegenerative diseases - Developed and validated a PROTAC-based assay as a therapy for neurodegenerative diseases - Performed binding assays to analyse aggregation, stability, biomolecular interactions, and kinetics - Patented a group of molecules with diagnostic and therapeutic applications in neurodegenerative diseases - Documented protocols and experimental results in accordance with good scientific practice - Planed, coordinated and monitored research projects - Authored one highlight publication, one peer-reviewed publication in press, and three preprints - Presented research findings via posters and oral presentations at international conferences - Supervised junior researchers and collaborated with international and multidisciplinary teams
- Performed protein purification and applied biophysical techniques to evaluate aggregation - Identified small molecules that inhibit protein aggregation using high-throughput screening - Assessed compound toxicity in cell-based assays - Determine neuroprotective effect of compounds in Caenorhabditis elegans model - Documented protocols and experimental results in accordance with good scientific practice
- Evaluated host-pathogen interaction in Drosophila melanogaster infected with Mycobacterium marinum - Analysed survival rates and bacterial load - Contributed to early-stage assessment for vaccine development - Documented protocols and experimental results in accordance with good scientific practice