J***********************a

Meerbusch , Kaarst, Meerbusch , Rhein-Kreis Neuss, North Rhine-Westphalia, Germany

Profil

Bildung

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PhD Candidate in Molecular Life Sciences 2020-2025
Utrecht Univerity

“FibrilPaint as a novel tool to unravel the molecular mechanism of neurodegenerative diseases” | Magna cum laude

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Master’s degree in Biochemistry, Molecular Biology and Biomedicine 2019-2020
Universitat Autònoma de Barcelona

Thesis: “Design and development of small molecules to target tau and α-synuclein aggregation” | Grade: 9.1/10

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Erasmus exchange programme 2018-2019
University Eastern Finland

35 ECTS credits in the master’s degree programme in Toxicology and master’s degree programme in Biomedicine

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Bachelor’s degree in Biotechnology 2015-2019
Universitat Autònoma de Barcelona

Thesis: “Study of Tuberculosis in Drosophila melanogaster model. Infection in Mycobacterium marinum” | Grade: 9.1/10

Erfahrungen

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PhD candidate Nov 2020 - Jun 2025

- Performed recombinant protein production and purification and brain-derived protein purification - Developed and validated a sensitive peptide-based assay for early diagnosis of neurodegenerative diseases - Developed and validated a PROTAC-based assay as a therapy for neurodegenerative diseases - Performed binding assays to analyse aggregation, stability, biomolecular interactions, and kinetics - Patented a group of molecules with diagnostic and therapeutic applications in neurodegenerative diseases - Documented protocols and experimental results in accordance with good scientific practice - Planed, coordinated and monitored research projects - Authored one highlight publication, one peer-reviewed publication in press, and three preprints - Presented research findings via posters and oral presentations at international conferences - Supervised junior researchers and collaborated with international and multidisciplinary teams

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Master’s degree intern Sep 2019 - Jul 2020

- Performed protein purification and applied biophysical techniques to evaluate aggregation - Identified small molecules that inhibit protein aggregation using high-throughput screening - Assessed compound toxicity in cell-based assays - Determine neuroprotective effect of compounds in Caenorhabditis elegans model - Documented protocols and experimental results in accordance with good scientific practice

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Bachelor’s degree intern Jun 2018 - Aug 2018

- Evaluated host-pathogen interaction in Drosophila melanogaster infected with Mycobacterium marinum - Analysed survival rates and bacterial load - Contributed to early-stage assessment for vaccine development - Documented protocols and experimental results in accordance with good scientific practice

Fertigkeiten

Design, development and validation of methods and assays
Protein production, purification and characterization
Analytical characterization of biomolecules
Biophysical techniques for aggregation, binding affinity and kinetics analysis: FIDA, DLS, MST, fluorescence-based assays
Drug development and biomarker discovery
Documentation, protocol adherences and data integrity management
Project planning, coordination, and execution
Mentorship and supervision
Collaboration in multidisciplinary and international teams
Scientific writing and oral communication
Analytical thinking and problem-solving
Attention to detail and responsibility for data quality
Adaptability and flexibility
Proactive learning